Anti-Self Phosphatidylserine Antibodies Recognize Uninfected Erythrocytes Promoting Malarial Anemia
نویسندگان
چکیده
منابع مشابه
Phosphatidylserine transport in Rhnull erythrocytes.
Phosphatidylserine transport in normal and Rhnull red blood cells was determined by measuring characteristic morphologic changes induced by synthetic phospholipids. Treating normal A+ cells with commercial anti-A antisera, anti-Rho(D) antisera, or with saturating concentrations of purified Rho(D) antibodies had no effect on phosphatidylserine transport. Normal B- cells treated with purified ant...
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Objective. To determine the prevalence and clinical association of anti-phosphatidylserine/prothrombin antibodies (aPS/PT) in patients with a history of pregnancy complications relevant to antiphospholipid syndrome (APS). Materials and Methods. Two hundred and eleven patients with a history of (a) three or more consecutive miscarriages before 10th week of gestation (WG) (n = 64), (b) death of a...
متن کاملMalarial anemia and STAT6.
M alaria infection places a huge economic burden on the developing world. It has been estimated that annually there are over 500 million episodes and it is responsible for 18% of childhood deaths in sub-Saharan Africa. 1 Infection in the human host is initiated by a bite from a female anopheline mosquito during which sporozoites enter the body and home to the liver initiating the hepatic phase ...
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Mast cells that accumulate cholesterol precursors in their membranes tend to overreact, according to Kovarova and colleagues on page 1161. This mast cell hyperresponsiveness might help explain why patients with a genetic disease known as Smith-Lemli-Opitz syndrome (SLOS) are prone to food allergies. Patients with SLOS have abnormally low levels of circulating cholesterol— and a corresponding ab...
متن کاملAnti-phosphatidylserine-prothrombin complex antibodies in patients with localized scleroderma.
OBJECTIVE Although some antiphospholipid antibodies (Abs) are found in patients with localized scleroderma (LSc), Ab against phosphatidylserine-prothrombin complex (PS/PT) has not been examined. We investigated anti-PS/PT Ab levels in patients with LSc. METHODS IgG anti-PS/PT Ab levels in serum samples taken from patients with LSc (n = 42) were measured using ELISA. RESULTS IgG anti-PS/PT A...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2016
ISSN: 1931-3128
DOI: 10.1016/j.chom.2016.01.009